DESCRIPTION. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Generic Name: Bupropion HCL (byoo-PROE-pee-on) Drug Class: Antidepressant, Miscellaneous Table of Contents Overview How to Take It Side Effects Warnings & Wellbutrin (bupropion) is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. Wellbutrin may also be used for purposes not listed in this medication guide. Doctors' Answers to Frequently Asked Questions - Wellbutrin. These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. The Wellbutrin brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available. Bupropion (Aplenzin, Wellbutrin, Wellbutrin SR, Wellbutrin XL) is used to treat depression. Bupropion (Aplenzin, Wellbutrin XL) is also used to treat seasonal affective disorder (SAD; episodes of depression that occur at the same time each year [usually in the fall and winter but rarely may occur in the spring or summer months]). Wellbutrin (Bupropion) is an antidepressant medication used for treating depression and seasonal affective disorder (SAD). Wellbutrin is an antidepressant in the aminoketone class used for the management of major depression and seasonal affective disorder. Wellbutrin is available in generic form. BUPROPION is used to treat depression. The lowest GoodRx price for the most common version of generic Wellbutrin SR is around $9.00, 88% off the average retail price of $75.90. Describes the medication bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Forfivo XL) an antidepressant drug used to manage depression, and also to help with smoking cessation. Article includes descriptions, uses, drug interactions, and side effects.